Holman Illustrated Bible Dictionary

Nonpoisonous but bitter plant common to the Middle East. Wormwood often is used in analogy to speak of bitterness and sorrow. OT prophets pictured wormwood as the opposite of justice and righteousness (Amos 5:7;Jer. 23:15). Revelation describes as wormwood one of the blazing stars that brings destruction (Rev. 8:10-11).

Deuteronomy
29:18 Lest there should be among you man, or woman, or family, or tribe, whose heart turneth away this day from the LORD our God, to go and serve the gods of these nations; lest there should be among you a root that beareth gall and wormwood;

29:19 And it come to pass, when he heareth the words of this curse, that he bless himself in his heart, saying, I shall have peace, though I walk in the imagination of mine heart, to add drunkenness to thirst:

29:20 The LORD will not spare him, but then the anger of the LORD and his jealousy shall smoke against that man, and all the curses that are written in this book shall lie upon him, and the LORD shall blot out his name from under heaven.

Proverbs
5:1 My son, attend unto my wisdom, and bow thine ear to my understanding:

5:2 That thou mayest regard discretion, and that thy lips may keep knowledge.

5:3 For the lips of a strange woman drop as an honeycomb, and her mouth is smoother than oil:

5:4 But her end is bitter as wormwood, sharp as a twoedged sword.

5:5 Her feet go down to death; her steps take hold on hell.

Jeremiah
9:13 And the LORD saith, Because they have forsaken my law which I set before them, and have not obeyed my voice, neither walked therein;

9:14 But have walked after the imagination of their own heart, and after Baalim, which their fathers taught them:

9:15 Therefore thus saith the LORD of hosts, the God of Israel; Behold, I will feed them, even this people, with wormwood, and give them water of gall to drink.

Lamentations
3:15 He hath filled me with bitterness, he hath made me drunken with wormwood.

3:16 He hath also broken my teeth with gravel stones, he hath covered me with ashes.

3:17 And thou hast removed my soul far off from peace: I forgat prosperity.

3:18 And I said, My strength and my hope is perished from the LORD:

3:19 Remembering mine affliction and my misery, the wormwood and the gall.

Amos
5:7 Ye who turn judgment to wormwood, and leave off righteousness in the earth,

Jeremiah
23:15 Therefore thus saith the LORD of hosts concerning the prophets; Behold, I will feed them with wormwood, and make them drink the water of gall: for from the prophets of Jerusalem is profaneness gone forth into all the land.

Revelation
8:10 And the third angel sounded, and there fell a great star from heaven, burning as it were a lamp, and it fell upon the third part of the rivers, and upon the fountains of waters;

8:11 And the name of the star is called Wormwood: and the third part of the waters became wormwood; and many men died of the waters, because they were made bitter.